Custom process                     development ahead of large          batch manufacturing            

Optimisation enables scalable manufacturing​​

We run high throughput upstream optimisation before every large batch. The scope is dependent on developer goals so that we can meet different product attributes.

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We read out both yield (via dPCR), and quality (via mass photometry) for each process condition and process step.​

Fig 1

Completed NHP-grade batches​​​​​​

Displayed are three large manufacturing batches (1-4e14 vg). After optimization, we obtain a high proportion of full capsids after purification using chromatography (Fig 2).

Final mass photometry data for a large-batch AAV9 project and associated CoA is displayed in the top two panels.  The bottom two panels show mass photometry plots for two other large-batch projects: an undisclosed known serotype (left), and undisclosed engineered capsid that was refractory to methods used to purify the serotype it derived from (right).

Fig 2